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LILETTA® is a sterile, levonorgestrel-releasing intrauterine system indicated for prevention of pregnancy for up to 6 years. The system should be replaced after 6 years if continued use is desired.
*LILETTA is an intrauterine system, or IUS, otherwise known as an IUD, intrauterine device
Open-label, multicenter trial conducted at 29 U.S. study centers over 72 months (N=1751)
Efficacy of LILETTA for pregnancy prevention in nulliparous and parous females of childbearing potential (16-35 years old)
Safety and bleeding patterns
Return of menses after discontinuation
The ACCESS IUS trial studied LILETTA in 1751 generally healthy patients.1
Pregnancy rate calculated as the Pearl Index was the primary efficacy endpoint in women aged 16-35.
‡Patients should be counseled to check that LILETTA is in the proper position by feeling the threads once a month. Healthcare providers should re-examine and evaluate patients 4 to 6 weeks after insertion and once a year thereafter, or more frequently if clinically indicated.
Data based on an analysis of 191 women who desired pregnancy after study discontinuation. Conception rates after removal of LILETTA were assessed and appeared consistent with conception rates in the general population of women having regular, unprotected sexual intercourse for 12 months.
References: 1. LILETTA (levonorgestrel-releasing intrauterine system) 52 mg [prescribing information]. Irvine, CA: Allergan USA, Inc., and San Francisco, CA: Medicines360; 2020. 2. Mirena (levonorgestrel-releasing intrauterine system) 52 mg [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc., 2021. 3. Kyleena (levonorgestrel-releasing intrauterine system) 19.5 mg [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc., 2021. 4. Skyla (levonorgestrel-releasing intrauterine system) 13.5 mg [prescribing information]. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc., 2021. 5. Data on file. Medicines360: San Francisco, CA.
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